Datasets:

bio-protocol
/

neophyte-faiss-index-v1

chunk_id string	chunk_hash int64	text string	paper_id string	title string	section string	subsection string	paragraph_index int64	keywords string	boost float32
10.1016/j.mtbio.2023.100582:::title::::::0:::0	8,650,399,219,291,345,000	Recent progress of antibacterial hydrogels in wound dressings — TITLE Recent progress of antibacterial hydrogels in wound dressings	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	title	null	0	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1
10.1016/j.mtbio.2023.100582:::abstract::::::0:::0	5,342,171,232,047,600,000	Recent progress of antibacterial hydrogels in wound dressings — ABSTRACT Hydrogels are hydrophilic three-dimensional polymer networks that combine favorable biocompatibility, mechanical properties resembling soft tissue extracellular matrix, and intrinsic tissue repair advantages. In skin wound management, hydrogels e...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	abstract	null	0	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1.3
10.1016/j.mtbio.2023.100582:::abstract::::::0:::1	8,585,301,118,761,914,000	Recent progress of antibacterial hydrogels in wound dressings — ABSTRACT In skin wound management, hydrogels endowed with antibacterial functions are particularly attractive as wound dressings because they can provide a moist healing environment, absorb exudate, promote hemostasis and re-epithelialization, and reduce ...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	abstract	null	0	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1.3
10.1016/j.mtbio.2023.100582:::abstract::::::0:::2	-2,542,734,020,010,896,000	Recent progress of antibacterial hydrogels in wound dressings — ABSTRACT This review summarizes recent progress in the design and fabrication of antibacterial hydrogel wound dressings, emphasizing (i) crosslinking strategies and how they determine mechanical/stability properties and functionality (permanent covalent, ...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	abstract	null	0	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1.3
10.1016/j.mtbio.2023.100582:::abstract::::::0:::3	-1,576,778,824,061,910,000	Recent progress of antibacterial hydrogels in wound dressings — ABSTRACT Representative hydrogel forms (microneedles, Janus patches, nanofiber-reinforced hydrogels, injectable matrices, sponge and film dressings) and typical mechanical properties of single-, double-, and multi-network hydrogels are summarized. We disc...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	abstract	null	0	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1.3
10.1016/j.mtbio.2023.100582:::introduction::::::0:::0	-5,288,796,335,111,715,000	Recent progress of antibacterial hydrogels in wound dressings — INTRODUCTION Hydrogels are highly hydrophilic, three-dimensional network polymers that possess good biocompatibility, high water uptake (swelling), and mechanical behavior similar to the extracellular matrix of soft tissues [1-9]. As wound dressings, hydr...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	introduction	null	0	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1
10.1016/j.mtbio.2023.100582:::introduction::::::1:::0	8,217,809,097,628,531,000	Recent progress of antibacterial hydrogels in wound dressings — INTRODUCTION Skin barrier disruption makes wounds susceptible to colonization and infection by a variety of microorganisms (bacteria, fungi, viruses) from the external environment [24-26]. Common wound pathogens include Staphylococcus aureus, streptococci...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	introduction	null	1	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1
10.1016/j.mtbio.2023.100582:::introduction::::::1:::1	738,873,492,903,187,600	Recent progress of antibacterial hydrogels in wound dressings — INTRODUCTION Localized antibacterial delivery at the wound site—using materials that either are themselves antibacterial or that release antibacterial agents—can reduce systemic exposure and support efficient bacterial control. Antibacterial hydrogel dres...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	introduction	null	1	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1
10.1016/j.mtbio.2023.100582:::introduction::::::1:::2	860,791,712,652,414,300	Recent progress of antibacterial hydrogels in wound dressings — INTRODUCTION Antibacterial hydrogel dressings are commonly classified by (i) source of antibacterial action: inherent antibacterial hydrogels (the matrix itself has antibacterial activity), agent-release hydrogels (antibacterial drugs, metal ions, nanopar...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	introduction	null	1	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1
10.1016/j.mtbio.2023.100582:::introduction::::::2:::0	-1,628,761,503,661,308,400	Recent progress of antibacterial hydrogels in wound dressings — INTRODUCTION This review synthesizes recent advances in crosslinking strategies and material choices for antibacterial hydrogel wound dressings, summarizes the principal antibacterial components and mechanisms used in hydrogels, reviews stimulus-responsiv...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	introduction	null	2	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1
10.1016/j.mtbio.2023.100582:::results::::::0:::0	-3,428,623,637,175,457,000	Recent progress of antibacterial hydrogels in wound dressings — RESULTS Overview: antibacterial hydrogel wound dressings obtain antibacterial activity either from intrinsic antibacterial matrix components, from loaded/released antimicrobial agents, or from stimulus-triggered antibacterial modalities. Below we summariz...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	results	null	0	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1.3
10.1016/j.mtbio.2023.100582:::results::::::0:::1	-9,003,373,857,181,364,000	Recent progress of antibacterial hydrogels in wound dressings — RESULTS Chitosan—a cationic polysaccharide obtained by deacetylation of chitin—exerts antibacterial activity via protonated amino groups that interact electrostatically with negatively charged bacterial membranes and can disrupt membrane integrity. For ex...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	results	null	0	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1.3
10.1016/j.mtbio.2023.100582:::results::::::0:::2	-6,152,415,992,665,940,000	Recent progress of antibacterial hydrogels in wound dressings — RESULTS Tannic acid, a polyphenol, contributes via hydrogen bonding within hydrogels (imparting adhesion and cohesion) and via direct antibacterial and antioxidant action on bacterial cell envelopes; composite hydrogels containing tannic acid have shown s...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	results	null	0	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1.3
10.1016/j.mtbio.2023.100582:::results::::::1:::0	5,919,064,886,345,679,000	Recent progress of antibacterial hydrogels in wound dressings — RESULTS Synthetic polymer–based inherent antibacterial hydrogels: Synthetic antibacterial motifs (ionic liquids, quaternary ammonium salts, N-halamines, imidazolium derivatives, biguanides, phenolic and nitrile chemistries) have been incorporated into hyd...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	results	null	1	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1.3
10.1016/j.mtbio.2023.100582:::results::::::2:::0	7,661,942,086,519,383,000	Recent progress of antibacterial hydrogels in wound dressings — RESULTS Hydrogels modified with antibacterial groups: When base matrices lack antibacterial activity (e.g., polyvinyl alcohol), covalent grafting of antibacterial monomers (quaternary ammonium monomers, guanidine-based monomers, imidazolium monomers) has ...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	results	null	2	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1.3
10.1016/j.mtbio.2023.100582:::results::::::2:::1	-8,116,566,410,493,819,000	Recent progress of antibacterial hydrogels in wound dressings — RESULTS remain widely used because of broad-spectrum activity mediated by protein/DNA binding and ROS generation. Silver nanoparticles incorporated in PVA/starch matrices or immobilized via polydopamine coatings provide sustained release and strong bacter...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	results	null	2	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1.3
10.1016/j.mtbio.2023.100582:::results::::::3:::0	-728,056,911,412,881,900	Recent progress of antibacterial hydrogels in wound dressings — RESULTS Antibiotic-loaded hydrogels: Antibiotics remain efficient when delivered locally to wounds. Hydrogels serve as reservoirs for antibiotics (vancomycin, gentamicin, ciprofloxacin, tobramycin) enabling local, sustained release and reduced systemic ex...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	results	null	3	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1.3
10.1016/j.mtbio.2023.100582:::results::::::3:::1	4,704,917,768,719,927,000	Recent progress of antibacterial hydrogels in wound dressings — RESULTS Examples include HHC-36 incorporated with cerium oxide nanoparticles into catechol-functionalized GelMA to yield >99% antibacterial activity while ceria scavenged ROS and supported healing [210]. pH-sensitive DP7 peptide/dextran hydrogels synergiz...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	results	null	3	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1.3
10.1016/j.mtbio.2023.100582:::results::::::4:::0	3,578,481,120,038,392,000	Recent progress of antibacterial hydrogels in wound dressings — RESULTS 3) Stimulus-responsive antibacterial hydrogels Photo-responsive hydrogels: Photothermal agents (PTAs) and photodynamic agents (PDAs) incorporated into hydrogels enable light-triggered antibacterial action. PTAs (graphene oxide, gold, CuS, black p...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	results	null	4	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1.3
10.1016/j.mtbio.2023.100582:::results::::::5:::0	-5,091,508,305,803,046,000	Recent progress of antibacterial hydrogels in wound dressings — RESULTS Acoustic (sonodynamic) responsive hydrogels: Ultrasound provides deeper tissue penetration and can activate sonosensitizers to produce ROS via sonoluminescence or cavitation. Hydrogels conjugating catalase with meso-tetra(4-carboxyphenyl)porphyrin...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	results	null	5	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1.3
10.1016/j.mtbio.2023.100582:::results::::::6:::0	1,970,976,102,218,467,000	Recent progress of antibacterial hydrogels in wound dressings — RESULTS Representative dressing formats: hydrogels have been cast or fabricated into microneedle arrays (detachable, for programmed delivery), Janus patches (asymmetric inner/outer layers for combined local treatment and barrier protection), nanofiber-rei...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	results	null	6	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1.3
10.1016/j.mtbio.2023.100582:::discussion::::::0:::0	828,647,471,892,496,400	Recent progress of antibacterial hydrogels in wound dressings — DISCUSSION Synthesis of lessons and critical analysis Crosslinking architecture and functional trade-offs: Permanent covalent hydrogels provide mechanical robustness and slow degradation, which is beneficial when long-term structural barrier function is ...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	discussion	null	0	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1
10.1016/j.mtbio.2023.100582:::discussion::::::0:::1	-110,884,707,519,247,660	Recent progress of antibacterial hydrogels in wound dressings — DISCUSSION Antibacterial strategies: inherent antibacterial hydrogels (cationic polymers, antimicrobial peptides, phenolic compounds) minimize agent release and lower systemic exposure, which can reduce selection pressure for resistance. However, many inh...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	discussion	null	0	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1
10.1016/j.mtbio.2023.100582:::discussion::::::1:::0	-7,846,682,583,003,011,000	Recent progress of antibacterial hydrogels in wound dressings — DISCUSSION Material safety and translational barriers: For clinical translation, cytocompatibility, hemocompatibility, controllable biodegradation and lack of harmful long-term residues are critical. Metals (Ag, Cu) and some synthetic antibacterial motifs...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	discussion	null	1	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1
10.1016/j.mtbio.2023.100582:::discussion::::::1:::1	-4,942,291,089,655,971,000	Recent progress of antibacterial hydrogels in wound dressings — DISCUSSION Single networks can be suitable for low-load, superficial wounds, whereas DN, TN and multi-network hydrogels are better suited to mechanically demanding sites (joints, wounds subject to motion). Adhesive strength, burst pressure and lap-shear s...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	discussion	null	1	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1
10.1016/j.mtbio.2023.100582:::discussion::::::2:::0	9,141,666,195,132,154,000	Recent progress of antibacterial hydrogels in wound dressings — DISCUSSION Recommended priorities for future research and development 1) Broader and standardized antibacterial testing: many studies test only S. aureus and E. coli. To better understand clinical relevance, researchers should test against a broader pane...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	discussion	null	2	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1
10.1016/j.mtbio.2023.100582:::discussion::::::3:::0	-2,680,449,133,484,764,000	Recent progress of antibacterial hydrogels in wound dressings — DISCUSSION 4) Scalability, sterilization and regulatory considerations: robust synthetic routes, scalable fabrication (e.g., molding, printing, roll-to-roll processing), sterilization compatibility (gamma, ethylene oxide, autoclave where appropriate) and ...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	discussion	null	3	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1
10.1016/j.mtbio.2023.100582:::discussion::::::4:::0	-4,718,526,084,499,116,000	Recent progress of antibacterial hydrogels in wound dressings — DISCUSSION Limitations of current literature: many reports focus on proof-of-concept materials and short-term animal models; long-term safety, chronic wound models (e.g., diabetic wounds), realistic bacterial loads and biofilm challenges, and head-to-head...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	discussion	null	4	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1
10.1016/j.mtbio.2023.100582:::conclusion::::::0:::0	2,513,854,706,749,116,400	Recent progress of antibacterial hydrogels in wound dressings — CONCLUSION Antibacterial hydrogels offer a versatile and powerful platform for wound management by combining physical protection, moisture balance and targeted antibacterial strategies. Crosslinking chemistry (permanent covalent, dynamic covalent, physica...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	conclusion	null	0	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1.3
10.1016/j.mtbio.2023.100582:::methods:::Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for drug loading and controlled release ...	3,225,338,195,909,776,400	Recent progress of antibacterial hydrogels in wound dressings — METHODS / Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for dr...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	methods	Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for drug loading and controlled release [44-47]. Designing antibacterial hydroge...	0	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	0.9
10.1016/j.mtbio.2023.100582:::methods:::Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for drug loading and controlled release ...	6,558,515,183,228,225,000	Recent progress of antibacterial hydrogels in wound dressings — METHODS / Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for dr...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	methods	Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for drug loading and controlled release [44-47]. Designing antibacterial hydroge...	0	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	0.9
10.1016/j.mtbio.2023.100582:::methods:::Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for drug loading and controlled release ...	-3,589,277,226,089,752,600	Recent progress of antibacterial hydrogels in wound dressings — METHODS / Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for dr...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	methods	Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for drug loading and controlled release [44-47]. Designing antibacterial hydroge...	1	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	0.9
10.1016/j.mtbio.2023.100582:::methods:::Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for drug loading and controlled release ...	-8,577,680,980,965,900,000	Recent progress of antibacterial hydrogels in wound dressings — METHODS / Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for dr...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	methods	Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for drug loading and controlled release [44-47]. Designing antibacterial hydroge...	1	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	0.9
10.1016/j.mtbio.2023.100582:::methods:::Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for drug loading and controlled release ...	2,295,385,456,866,528,500	Recent progress of antibacterial hydrogels in wound dressings — METHODS / Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for dr...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	methods	Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for drug loading and controlled release [44-47]. Designing antibacterial hydroge...	2	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	0.9
10.1016/j.mtbio.2023.100582:::methods:::Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for drug loading and controlled release ...	6,779,314,185,957,410,000	Recent progress of antibacterial hydrogels in wound dressings — METHODS / Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for dr...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	methods	Overview: the fabrication method and crosslinking chemistry of a hydrogel determine its basic wound-dressing performance: adhesion, mechanical strength and toughness, swelling behavior, hemostatic capability, degradation rate, and capacity for drug loading and controlled release [44-47]. Designing antibacterial hydroge...	3	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	0.9
10.1016/j.mtbio.2023.100582:::supplementary::::::0:::0	-9,207,135,480,966,198,000	Recent progress of antibacterial hydrogels in wound dressings — SUPPLEMENTARY The original manuscript referenced supplementary figures/tables that were not included in the source provided; these are indicated in the text where appropriate (not included in this document). Researchers interested in the primary data and ...	10.1016/j.mtbio.2023.100582	Recent progress of antibacterial hydrogels in wound dressings	supplementary	null	0	["Antibacterial hydrogels", "Wound dressings", "Preparation methods", "Antibacterial strategies", "Applications"]	1
10.1016/j.biotno.2022.07.002:::title::::::0:::0	3,608,978,084,385,519,000	Synthetic biology landscape in the UK — TITLE Synthetic biology landscape in the UK	10.1016/j.biotno.2022.07.002	Synthetic biology landscape in the UK	title	null	0	["synthetic biology", "engineering biology", "bioeconomy", "technology translation", "foundries", "UK"]	1
10.1016/j.biotno.2022.07.002:::abstract::::::0:::0	8,310,654,753,162,074,000	Synthetic biology landscape in the UK — ABSTRACT The United Kingdom hosts a diverse and active synthetic biology community spanning academic research centres, student societies, accelerators, incubators, genome foundries and government policy bodies. This review maps the organisations and networks that underpin the UK...	10.1016/j.biotno.2022.07.002	Synthetic biology landscape in the UK	abstract	null	0	["synthetic biology", "engineering biology", "bioeconomy", "technology translation", "foundries", "UK"]	1.3
10.1016/j.biotno.2022.07.002:::introduction::::::0:::0	1,575,736,195,379,516,700	Synthetic biology landscape in the UK — INTRODUCTION Background and aims Synthetic biology has matured over the past two decades from a nascent discipline into a broad engineering approach to biology. Two widely cited early studies from 2000—the genetic "Toggle Switch" and the "Repressilator"—framed the ambition to d...	10.1016/j.biotno.2022.07.002	Synthetic biology landscape in the UK	introduction	null	0	["synthetic biology", "engineering biology", "bioeconomy", "technology translation", "foundries", "UK"]	1
10.1016/j.biotno.2022.07.002:::introduction::::::1:::0	5,714,606,642,389,744,000	Synthetic biology landscape in the UK — INTRODUCTION History and community formation Early UK engagement with the emerging synthetic‑biology community began in the mid‑2000s. The University of Cambridge fielded one of the first international iGEM teams (2005) and Imperial College London placed runner‑up in 2006 [9,10...	10.1016/j.biotno.2022.07.002	Synthetic biology landscape in the UK	introduction	null	1	["synthetic biology", "engineering biology", "bioeconomy", "technology translation", "foundries", "UK"]	1
10.1016/j.biotno.2022.07.002:::introduction::::::2:::0	-6,895,489,717,816,545,000	Synthetic biology landscape in the UK — INTRODUCTION Student societies and the next generation of founders Student‑founded societies are an important part of the UK ecosystem and often originate from iGEM teams or alumni networks. Examples include SynBio Imperial College, UCL BeakerSoc, the SynBio Society at the Univ...	10.1016/j.biotno.2022.07.002	Synthetic biology landscape in the UK	introduction	null	2	["synthetic biology", "engineering biology", "bioeconomy", "technology translation", "foundries", "UK"]	1
10.1016/j.biotno.2022.07.002:::introduction::::::3:::0	-2,342,012,438,371,934,000	Synthetic biology landscape in the UK — INTRODUCTION Translation infrastructure: accelerators, incubators, independent labs and foundries Translation in the UK is supported by a mix of global and local accelerators, dedicated biotech venture funds, academic commercialisation hubs, independent lab spaces and genome fo...	10.1016/j.biotno.2022.07.002	Synthetic biology landscape in the UK	introduction	null	3	["synthetic biology", "engineering biology", "bioeconomy", "technology translation", "foundries", "UK"]	1
10.1016/j.biotno.2022.07.002:::introduction::::::4:::0	-8,200,853,020,842,026,000	Synthetic biology landscape in the UK — INTRODUCTION Major UK genome foundries and distributed capabilities There are multiple high‑throughput foundries in the UK that provide services such as DNA synthesis, strain engineering and automated workflows. The principal foundries and their locations noted in the survey ar...	10.1016/j.biotno.2022.07.002	Synthetic biology landscape in the UK	introduction	null	4	["synthetic biology", "engineering biology", "bioeconomy", "technology translation", "foundries", "UK"]	1
10.1016/j.biotno.2022.07.002:::introduction::::::5:::0	-8,439,403,624,866,478,000	Synthetic biology landscape in the UK — INTRODUCTION The UK's bioeconomy, funding and policy context The UK government has identified biotechnology and related areas as national priorities for economic growth, food security, health and sustainability, and has set ambitions to expand the bioeconomy (for example, state...	10.1016/j.biotno.2022.07.002	Synthetic biology landscape in the UK	introduction	null	5	["synthetic biology", "engineering biology", "bioeconomy", "technology translation", "foundries", "UK"]	1
10.1016/j.biotno.2022.07.002:::introduction::::::6:::0	-1,594,224,729,991,305,200	Synthetic biology landscape in the UK — INTRODUCTION To bridge early funding gaps the UK has established a range of public‑sector funds and support programmes. Examples include Catapult centres (Innovate UK Catapult Network), Innovation to Commercialisation of University Research (ICURE), university and student compet...	10.1016/j.biotno.2022.07.002	Synthetic biology landscape in the UK	introduction	null	6	["synthetic biology", "engineering biology", "bioeconomy", "technology translation", "foundries", "UK"]	1
10.1016/j.biotno.2022.07.002:::introduction::::::7:::0	-6,444,771,491,487,274,000	Synthetic biology landscape in the UK — INTRODUCTION Intellectual property and tax incentives The UK offers tax incentives to encourage private investment: Enterprise Investment Scheme (EIS), Seed Enterprise Investment Scheme (SEIS), Social Investment Tax Relief (SITR) and Venture Capital Trusts (VCTs). For example, ...	10.1016/j.biotno.2022.07.002	Synthetic biology landscape in the UK	introduction	null	7	["synthetic biology", "engineering biology", "bioeconomy", "technology translation", "foundries", "UK"]	1
10.1016/j.biotno.2022.07.002:::discussion::::::0:::0	-8,216,854,767,737,320,000	Synthetic biology landscape in the UK — DISCUSSION Strengths of the UK ecosystem The UK synthetic‑biology ecosystem combines a strong academic base, a dense set of research centres, an active student and early‑career community and diverse translation pathways (incubators, accelerators, foundries and venture capital)....	10.1016/j.biotno.2022.07.002	Synthetic biology landscape in the UK	discussion	null	0	["synthetic biology", "engineering biology", "bioeconomy", "technology translation", "foundries", "UK"]	1
10.1016/j.biotno.2022.07.002:::discussion::::::1:::0	7,715,787,097,552,696,000	Synthetic biology landscape in the UK — DISCUSSION Recent UK changes to equity models and licensing In the last five years several UK universities have introduced more founder‑friendly models. Imperial College introduced a founder‑driven route in 2017 that permitted founders to retain up to 95% of company equity duri...	10.1016/j.biotno.2022.07.002	Synthetic biology landscape in the UK	discussion	null	1	["synthetic biology", "engineering biology", "bioeconomy", "technology translation", "foundries", "UK"]	1
10.1016/j.biotno.2022.07.002:::discussion::::::2:::0	7,412,993,321,971,089,000	Synthetic biology landscape in the UK — DISCUSSION Outstanding barriers and recommendations Despite improvements, several barriers remain: - Patenting and IP culture: The UK patents fewer inventions per unit of scientific output than the US. Strengthening IP management practices, earlier support for idea protection a...	10.1016/j.biotno.2022.07.002	Synthetic biology landscape in the UK	discussion	null	2	["synthetic biology", "engineering biology", "bioeconomy", "technology translation", "foundries", "UK"]	1
10.1016/j.biotno.2022.07.002:::discussion::::::3:::0	-5,458,662,296,901,726,000	Synthetic biology landscape in the UK — DISCUSSION Policy framing and the future of "engineering biology" The renaming of synthetic biology to "engineering biology" in many policy documents reflects a deliberate emphasis on engineering principles and industrial translation. This framing aligns government priorities w...	10.1016/j.biotno.2022.07.002	Synthetic biology landscape in the UK	discussion	null	3	["synthetic biology", "engineering biology", "bioeconomy", "technology translation", "foundries", "UK"]	1
10.1016/j.biotno.2022.07.002:::conclusion::::::0:::0	2,158,876,731,787,504,600	Synthetic biology landscape in the UK — CONCLUSION Summary and outlook The UK synthetic‑biology community is vibrant, diverse and increasingly well connected across universities, student societies, research centres, accelerators, foundries and government advisory bodies. Strengths include strong scientific output, an...	10.1016/j.biotno.2022.07.002	Synthetic biology landscape in the UK	conclusion	null	0	["synthetic biology", "engineering biology", "bioeconomy", "technology translation", "foundries", "UK"]	1.3
10.1016/j.biotno.2022.07.002:::conclusion::::::1:::0	3,654,808,249,988,349,400	Synthetic biology landscape in the UK — CONCLUSION With coordinated public‑private investment, a continued cultural shift toward supporting founder autonomy, and sustained emphasis on scale‑up capacity, the UK is well positioned to translate its scientific strengths into a globally competitive engineering‑biology indu...	10.1016/j.biotno.2022.07.002	Synthetic biology landscape in the UK	conclusion	null	1	["synthetic biology", "engineering biology", "bioeconomy", "technology translation", "foundries", "UK"]	1.3
10.1016/j.bioactmat.2023.11.021:::title::::::0:::0	-6,782,837,238,993,345,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — TITLE Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	title	null	0	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1
10.1016/j.bioactmat.2023.11.021:::abstract::::::0:::0	-7,035,138,714,314,776,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — ABSTRACT Intervertebral disc degeneration (IVDD) is a leading cause of spinal disability. The inflammatory microenvironment within the avascular disc is central to IVDD progression, driving extracellular matrix (ECM) catabolism, ce...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	abstract	null	0	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::abstract::::::0:::1	5,749,031,182,929,034,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — ABSTRACT Biomaterial-based delivery platforms — including nanoparticles, liposomes, nanomicelles, nanozymes, microspheres, hydrogels, electrospun fibers, and composite scaffolds — are being developed to locally and sustainably modu...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	abstract	null	0	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::introduction::::::0:::0	7,978,802,441,703,527,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — INTRODUCTION Background and normal structure. The intervertebral disc (IVD) is a hydrated fibrocartilaginous organ situated between vertebral bodies and consists of three principal components: the central nucleus pulposus (NP), the...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	introduction	null	0	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1
10.1016/j.bioactmat.2023.11.021:::introduction::::::1:::0	-5,273,895,142,422,318,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — INTRODUCTION Pathophysiology and role of inflammation in IVDD. Degeneration typically begins in the NP with proteoglycan degradation and loss of water-retaining notochordal cells, causing decreased NP hydration and altered biomecha...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	introduction	null	1	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1
10.1016/j.bioactmat.2023.11.021:::introduction::::::1:::1	5,747,534,310,872,599,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — INTRODUCTION Immune cell infiltration (macrophages, T cells, B cells), innate sensing, and resident cell secretion together create an inflammatory milieu characterized by elevated cytokines (TNF-α, IL-1α/β, IL-6, IFN-γ), chemokines...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	introduction	null	1	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1
10.1016/j.bioactmat.2023.11.021:::introduction::::::2:::0	9,133,510,519,195,473,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — INTRODUCTION Clinical problem and rationale for biomaterials. Conservative management (analgesics, physical therapy) often fails to halt degeneration and surgery can be invasive and biomechanically disruptive [5]. The avascular nat...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	introduction	null	2	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1
10.1016/j.bioactmat.2023.11.021:::results::::::0:::0	1,617,599,141,008,842,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS Overview. Multiple classes of anti-inflammatory interventions have been explored for IVDD: small-molecule drugs (glucocorticoids, NSAIDs), natural products and traditional medicines, biologics (cytokine antagonists, monoclo...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	0	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::0:::1	-7,091,839,703,082,723,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS Biomaterial carriers — natural polymers (HA, collagen/gelatin, chitosan, alginate, silk fibroin), synthetic polymers (PLA/PLGA, PCL, PEA, PVA, pNIPAAm, polyurethane), nanosystems (nanoparticles, liposomes, nanomicelles, nan...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	0	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::0:::2	-8,797,372,723,061,530,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS - Glucocorticoids: GCs inhibit phospholipase A2, suppress NF-κB and AP-1 activity, and modulate p38 MAPK signaling and macrophage cytokine production, reducing leukotriene and prostaglandin synthesis and attenuating neural ...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	0	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::0:::3	1,959,893,843,934,753,500	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS Aspirin and other NSAIDs downregulate MMP-3, MMP-13, iNOS, COX-2, IL-1β, and TNF-α in vitro and in animal models, suggesting potential to suppress disc inflammation and catabolism [70]. Selective COX-2 inhibitors (e.g., cel...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	0	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::0:::4	-6,517,590,748,413,254,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS Curcumin inhibits TNF-α/IL-1β, NF-κB, and COX-2 and reduces oxidative stress, but has poor solubility and bioavailability requiring carrier systems [75,76]. Ferulic acid suppresses NF-κB activation and downstream COX-2, iNO...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	0	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::0:::5	-7,063,273,121,403,357,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS - Biotherapy approaches (summary): IL-1 receptor antagonist (IL-1Ra) and TNF-α inhibitors block key proinflammatory cytokine signaling and reduce ECM degradation in vitro and in vivo models [92–99]. Enzyme-based strategies ...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	0	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::1:::0	-8,269,462,034,563,715,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS 2) Naturally derived polymer carriers. Natural polymers are favored for biocompatibility and bioactivity but often require reinforcement for load-bearing applications. - Hyaluronic acid (HA): a hydrophilic glycosaminoglycan...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	1	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::1:::1	-3,527,340,590,090,704,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS - Chitosan: a cationic polysaccharide with hemostatic and antimicrobial properties that forms temperature- and pH-responsive hydrogels suitable for controlled release and gene delivery; mechanical reinforcement is typically...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	1	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::2:::0	8,788,885,909,882,524,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS 3) Synthetic polymer carriers. Synthetic polymers impart tunable mechanics, degradation, and manufacturing reproducibility but can produce acidic degradation products or lack intrinsic bioactivity. - PLA/PLGA: widely used f...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	2	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::3:::0	1,438,536,604,568,350,700	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS 4) Nanodelivery systems (summary of representative examples in Table 2). Nanocarriers protect cargo, allow cellular uptake, and can be designed for stimulus responsiveness, targeting, and co-delivery of multiple cargo types...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	3	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::3:::1	-6,459,576,034,797,572,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS - Diclofenac-loaded nanoparticles (Df-NPs, 2016): used in bovine organ culture to downregulate IL-6/IL-8 and MMP1/MMP3 and reduce PGE2 while increasing ECM proteins [223,224]. - PLGA-ABT263 (2021): PLGA nanoparticles delive...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	3	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::3:::2	999,909,212,634,427,900	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS - LUT-pTGF-β1@PBC (2022): ROS-responsive poly(β-amino ester)-poly(ε-caprolactone) nanoparticles co-delivering luteolin and TGF-β1 pDNA; suppressed COX-2 and IL-6 and restored ECM anabolism/catabolism balance via TGF-β1 [202...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	3	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::3:::3	-4,952,489,149,314,464,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS - Oxymatrine-loaded liposomes (OMT-LIP, 2022): intravenous liposomal oxymatrine targeted inflammatory sites, reduced MMP3/9 and IL-6, mitigated ECM degeneration, and protected NP cells via NF-κB inhibition [209]. - siRNA li...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	3	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::4:::0	1,260,241,824,764,043,300	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS Mechanistic classes of nano-systems: liposomes protect proteins and nucleic acids but cationic lipids can be cytotoxic; nanomicelles encapsulate hydrophobic drugs and can be designed as enzyme-responsive carriers; nanozymes...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	4	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::4:::1	-7,854,537,780,309,458,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS 5) Microsphere-based delivery systems (summary of Table 3). Microspheres (≈1–250 μm) provide sustained release and can be fabricated from natural or synthetic polymers. Representative examples include: - EGCG-loaded gelatin...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	4	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::4:::2	-2,543,074,065,751,050,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS - psh-circSTC2-lipo@MS (2022): lipoplexes targeting circSTC2 grafted onto hyaluronic-acid–derived microspheres for in situ circRNA silencing to preserve ECM metabolism under nutrient-deficient conditions [234]. - NP-IC–seed...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	4	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::4:::3	5,747,366,218,567,740,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS - Catalase-loaded polymer capsules coated with tannic acid (2018): antioxidant capsules reduced proteolytic enzyme expression in IL-1β–stimulated NP inflammation models [242]. - Mg@PLPE MS (2023): ROS-responsive microsphere...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	4	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::5:::0	-7,234,603,084,623,823,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS Natural polymer microspheres (gelatin, HA, alginate) are biocompatible and can be functionalized with nanozymes or gene carriers to combine antioxidant, metabolic, and gene-silencing activities [232,234,236]. Synthetic micr...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	5	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::5:::1	-8,112,794,693,400,444,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS Hydrogels provide injectable, often tissue-mimetic matrices for sustained drug/cell/exosome delivery and can be designed to be stimuli-responsive, self-healing, or mechanically reinforced. - Naturally derived hydrogels: HA,...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	5	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::5:::2	-1,706,827,849,851,985,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS FibGen has been used as an AF sealant and a sustained-release vehicle for infliximab to reduce proinflammatory cytokines [98]. - Synthetic hydrogels: thermoresponsive pNIPAAm-MgFe layered double hydroxide hydrogels and PCLA...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	5	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::5:::3	5,720,472,393,839,846,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS ROS-scavenging hydrogels (e.g., rapamycin-loaded ROS-labile scaffolds) reduce M1 macrophages, upregulate Nrf2/Keap1 antioxidant signaling, and protect CEPs and NP cells from oxidative damage and senescence [255,256]. Compos...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	5	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::results::::::6:::0	6,660,650,525,185,885,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — RESULTS 7) Electrospun nanofibers for AF repair. Aligned electrospun fibers (commonly PCL) replicate AF lamellae and can be loaded with anti-inflammatory agents (ibuprofen, berberine, fucoidan) and growth factors (TGF-β3) in core–s...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	results	null	6	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::discussion::::::0:::0	1,999,261,815,752,148,500	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — DISCUSSION Advantages of biomaterial-enabled anti-inflammatory strategies. Biomaterials address critical limitations of systemic or direct intradiscal administration by (1) prolonging local residence time, (2) protecting labile car...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	discussion	null	0	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1
10.1016/j.bioactmat.2023.11.021:::discussion::::::0:::1	7,946,331,321,016,689,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — DISCUSSION - Preclinical models: Needle-puncture models are convenient but imperfectly mimic human IVDD etiology and chronicity. Mechanically induced, age-related, and genetically predisposed models (and large-animal models that re...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	discussion	null	0	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1
10.1016/j.bioactmat.2023.11.021:::discussion::::::0:::2	7,351,882,595,447,224,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — DISCUSSION - Delivery and containment: Ensuring intradiscal placement without leakage, providing AF repair/sealants where needle puncture risks re-leakage, and controlling burst release remain practical issues. - Hostile microenvir...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	discussion	null	0	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1
10.1016/j.bioactmat.2023.11.021:::discussion::::::1:::0	-831,511,872,836,209,900	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — DISCUSSION Key priorities and research directions. The literature suggests several priorities to accelerate translation: 1. Develop multifunctional platforms that combine anti-inflammatory, antioxidant, immunomodulatory, and pro-re...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	discussion	null	1	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1
10.1016/j.bioactmat.2023.11.021:::discussion::::::2:::0	-6,088,384,591,077,365,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — DISCUSSION Overall, while biomaterial-based anti-inflammatory approaches show strong mechanistic rationale and encouraging preclinical efficacy, careful optimization of materials, cargos, delivery methods, and translational models ...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	discussion	null	2	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1
10.1016/j.bioactmat.2023.11.021:::conclusion::::::0:::0	-3,235,007,207,592,660,500	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — CONCLUSION Modulating the inflammatory microenvironment with biomaterial-enabled delivery systems is a promising strategy to delay IVDD progression and support tissue regeneration. Injectable, stimuli-responsive, and composite biom...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	conclusion	null	0	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	1.3
10.1016/j.bioactmat.2023.11.021:::methods:::methods:::0:::0	4,281,304,200,657,459,000	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration — METHODS / methods This manuscript is a narrative review synthesizing published preclinical and translational literature on inflammatory mechanisms in IVDD and biomaterial-based therapeutic strategies. The original source did not pr...	10.1016/j.bioactmat.2023.11.021	Progress in regulating inflammatory biomaterials for intervertebral disc regeneration	methods	methods	0	["Intervertebral disc", "Anti-Inflammation", "Biomaterials", "Tissue regeneration"]	0.9
10.1016/j.isci.2020.101519:::title::::::0:::0	1,210,653,036,923,139,000	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity — TITLE Immune Literacy: Reading, Writing, and Editing Adaptive Immunity	10.1016/j.isci.2020.101519	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity	title	null	0	["immune repertoire sequencing", "immunoinformatics", "immunogenomic engineering", "B cell receptor (BCR)", "T cell receptor (TCR)", "single-cell sequencing", "CRISPR", "display technologies", "synthetic immunity", "machine learning"]	1
10.1016/j.isci.2020.101519:::abstract::::::0:::0	1,099,735,987,893,595,900	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity — ABSTRACT Advances in reading, writing, and editing DNA are providing unprecedented insights into the complexity of immunological systems. This combination of systems and synthetic biology methods is enabling quantitative and precise understanding of mo...	10.1016/j.isci.2020.101519	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity	abstract	null	0	["immune repertoire sequencing", "immunoinformatics", "immunogenomic engineering", "B cell receptor (BCR)", "T cell receptor (TCR)", "single-cell sequencing", "CRISPR", "display technologies", "synthetic immunity", "machine learning"]	1.3
10.1016/j.isci.2020.101519:::introduction::::::0:::0	6,542,554,000,661,615,000	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity — INTRODUCTION Adaptive immunity is mediated primarily by B and T lymphocytes, which mount molecularly targeted responses against pathogens and provide both short-term and long-term protection. Antigen recognition and specificity are encoded in adaptive ...	10.1016/j.isci.2020.101519	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity	introduction	null	0	["immune repertoire sequencing", "immunoinformatics", "immunogenomic engineering", "B cell receptor (BCR)", "T cell receptor (TCR)", "single-cell sequencing", "CRISPR", "display technologies", "synthetic immunity", "machine learning"]	1
10.1016/j.isci.2020.101519:::introduction::::::1:::0	8,162,050,174,578,470,000	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity — INTRODUCTION Rapid technological progress in sequencing, single-cell profiling, computational analysis, and genome engineering is transforming how adaptive immunity is read, written, and edited. High-throughput immune-repertoire sequencing and single-c...	10.1016/j.isci.2020.101519	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity	introduction	null	1	["immune repertoire sequencing", "immunoinformatics", "immunogenomic engineering", "B cell receptor (BCR)", "T cell receptor (TCR)", "single-cell sequencing", "CRISPR", "display technologies", "synthetic immunity", "machine learning"]	1
10.1016/j.isci.2020.101519:::introduction::::::1:::1	-4,929,769,308,357,648,000	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity — INTRODUCTION 2018; Li et al., 2019). The review that follows summarizes the current state of these complementary approaches—reading, writing, and editing adaptive immunity—highlights representative methods and platforms, and outlines translational oppo...	10.1016/j.isci.2020.101519	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity	introduction	null	1	["immune repertoire sequencing", "immunoinformatics", "immunogenomic engineering", "B cell receptor (BCR)", "T cell receptor (TCR)", "single-cell sequencing", "CRISPR", "display technologies", "synthetic immunity", "machine learning"]	1
10.1016/j.isci.2020.101519:::discussion::::::0:::0	-4,691,504,896,336,666,000	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity — DISCUSSION This review frames adaptive-immunity research around three complementary capabilities: reading (sequencing and single-cell profiling), writing (synthetic library generation and display), and editing (genome-engineering of immune cells). Each...	10.1016/j.isci.2020.101519	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity	discussion	null	0	["immune repertoire sequencing", "immunoinformatics", "immunogenomic engineering", "B cell receptor (BCR)", "T cell receptor (TCR)", "single-cell sequencing", "CRISPR", "display technologies", "synthetic immunity", "machine learning"]	1
10.1016/j.isci.2020.101519:::discussion::::::1:::0	-6,333,004,601,675,463,000	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity — DISCUSSION A central computational challenge for reading is accurate error correction and germline assignment. Sequencing and PCR errors artificially inflate apparent clonal diversity and can confound downstream analyses; UMIs and consensus-based error...	10.1016/j.isci.2020.101519	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity	discussion	null	1	["immune repertoire sequencing", "immunoinformatics", "immunogenomic engineering", "B cell receptor (BCR)", "T cell receptor (TCR)", "single-cell sequencing", "CRISPR", "display technologies", "synthetic immunity", "machine learning"]	1
10.1016/j.isci.2020.101519:::discussion::::::1:::1	6,288,949,890,534,959,000	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity — DISCUSSION 2017). Machine-learning approaches—supervised and unsupervised—exploit labeled antigen-specific data to build classifiers and generative models for specificity prediction and for designing variants with improved properties (Friedensohn et al...	10.1016/j.isci.2020.101519	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity	discussion	null	1	["immune repertoire sequencing", "immunoinformatics", "immunogenomic engineering", "B cell receptor (BCR)", "T cell receptor (TCR)", "single-cell sequencing", "CRISPR", "display technologies", "synthetic immunity", "machine learning"]	1
10.1016/j.isci.2020.101519:::discussion::::::2:::0	-6,724,216,095,388,396,000	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity — DISCUSSION Writing: display technologies and library screening Phage and yeast display remain central tools for in vitro selection of antigen-binding receptors. Phage can present very large libraries (up to ~10^11 variants), enabling broad exploration ...	10.1016/j.isci.2020.101519	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity	discussion	null	2	["immune repertoire sequencing", "immunoinformatics", "immunogenomic engineering", "B cell receptor (BCR)", "T cell receptor (TCR)", "single-cell sequencing", "CRISPR", "display technologies", "synthetic immunity", "machine learning"]	1
10.1016/j.isci.2020.101519:::discussion::::::3:::0	9,138,759,064,226,384,000	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity — DISCUSSION Mammalian-display approaches and endogenous-locus targeting (CRISPR-based HDR) enable screening in a more physiological expression context and permit simultaneous display and secretion of full-length IgG (Pogson et al., 2016; Parola et al., ...	10.1016/j.isci.2020.101519	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity	discussion	null	3	["immune repertoire sequencing", "immunoinformatics", "immunogenomic engineering", "B cell receptor (BCR)", "T cell receptor (TCR)", "single-cell sequencing", "CRISPR", "display technologies", "synthetic immunity", "machine learning"]	1
10.1016/j.isci.2020.101519:::discussion::::::3:::1	3,713,636,446,289,053,000	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity — DISCUSSION Nevertheless, there are tradeoffs: complete knockout of the endogenous TCR may reduce long-term persistence in some contexts (Stenger et al., 2020). Moreover, affinity-enhanced TCRs and CARs have caused severe off-target and on-target, off-t...	10.1016/j.isci.2020.101519	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity	discussion	null	3	["immune repertoire sequencing", "immunoinformatics", "immunogenomic engineering", "B cell receptor (BCR)", "T cell receptor (TCR)", "single-cell sequencing", "CRISPR", "display technologies", "synthetic immunity", "machine learning"]	1
10.1016/j.isci.2020.101519:::discussion::::::4:::0	5,419,240,961,447,633,000	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity — DISCUSSION B cell genome engineering is an emerging and promising direction for synthetic immunity because engineered B cells could function as in vivo factories producing protective antibodies. Early work demonstrated targeted nucleotide knock-ins and...	10.1016/j.isci.2020.101519	Immune Literacy: Reading, Writing, and Editing Adaptive Immunity	discussion	null	4	["immune repertoire sequencing", "immunoinformatics", "immunogenomic engineering", "B cell receptor (BCR)", "T cell receptor (TCR)", "single-cell sequencing", "CRISPR", "display technologies", "synthetic immunity", "machine learning"]	1

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neophyte-faiss-index-v1

A FAISS index + metadata for scientific retrieval

index.faiss: FAISS index (cosine w/ inner product).
meta.jsonl: one JSON per chunk; fields include chunk_id, paper_id, title, section, subsection, paragraph_index, keywords, boost.
index.info.json: (optional) dimensions, index type, faiss version.

Build provenance

Chunking: hierarchical (section→paragraph→~480-token chunks, ~15% overlap)
Embedder: bio-protocol/neophyte-retriever (mean-pooled, L2-normalized)
Similarity: cosine via inner product
FAISS type: IndexFlatIP (or your choice)

How to load

import faiss, json, numpy as np, hashlib
from huggingface_hub import hf_hub_download

REPO = "bio-protocol/neophyte-faiss-index-v1"
IDX  = hf_hub_download(REPO, "index.faiss", repo_type="dataset")
META = hf_hub_download(REPO, "meta.jsonl",  repo_type="dataset")
index = faiss.read_index(IDX)

# stable 64-bit ids (must match your build)
def stable64(s: str) -> int:
    try:
        import faiss
        if hasattr(faiss, "hash64"): return int(faiss.hash64(s))
    except Exception:
        pass
    return int.from_bytes(hashlib.blake2b(s.encode(), digest_size=8).digest(), "little", signed=False) - (1<<63)

id2meta = {}
with open(META, "r", encoding="utf-8") as f:
    for line in f:
        md = json.loads(line)
        id2meta[stable64(md["chunk_id"])]=md

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neophyte-faiss-index-v1

Contents

Build provenance

How to load

Collection including bio-protocol/neophyte-faiss-index-v1