zai-org/GLM-5.3
Text Generation • 753B • Updated • 50.1k • • 1.37k
Vladimir
vstiff
AI & ML interests
None yet
Recent Activity
new activity 25 minutes ago
unsloth/Qwen3.8-Flash-Next-GGUF:Qwen3.8-Flash-Next on Strix Halo: ~40 tok/s code at 120K+ context new activity 34 minutes ago
unsloth/Qwen3.8-Flash-Next-GGUF:strix halo 128gb recommendations liked a model 3 days ago
zai-org/GLM-5.3Organizations
None yet
Qwen3.8-Flash-Next on Strix Halo: ~40 tok/s code at 120K+ context
👍 8
1
#45 opened 2 days ago
by 
Engardium
strix halo 128gb recommendations
17
#28 opened 4 days ago
by 
dilavni
liked a
model 3 days ago
liked 2
models 5 days ago
rocm support
3
#1 opened 8 days ago
by 
idchrono
Love your models, any chance of something between 35b and 397b?
👍 5
4
#1 opened 12 days ago
by 
Shaunm89
reacted to SeaWolf-AI's post with 👍 12 days ago
Post
3982
3,631 candidate molecules arrived in five days, from 83 accounts — roughly 700 a day. Far more than we expected. Thank you.
Yesterday we opened the third season and 224 arrived within a day: Chagas disease.
Why this disease
Around 6 million people live with it, mostly in Latin America (WHO). Many carry it for decades without knowing, while the heart is slowly damaged. There are two drugs and both date from the 1960s, hard enough to tolerate that many patients cannot finish the two-month course.
Sixty years without a new drug is not only a scientific problem. Most patients live where development costs cannot be recovered, which is why WHO calls this a neglected tropical disease.
But the cost of proposing a candidate and filtering it has changed. So it seemed worth asking whether work nobody funds could be done by many people sharing it out.
The problem this season
The target is CYP51, the enzyme T. cruzi uses to build its membrane sterols. Block it and the parasite cannot survive. The difficulty is that we carry the same enzyme.
Scoring: binding 30 · selectivity 30 · ADMET 15 · whole-cell 10 · novelty 10 · synthesis 5
Selectivity carries 30 points because nobody has solved it. Among the approved azoles on the board as reference compounds, some score 0 on selectivity — not a scorer fault, but the measurement.
Taking part
Design with any model, submit a SMILES, scored within minutes. Five ready-to-paste prompts per season, and the full rubric is published. Your molecule stays yours; private submission is the default.
Prizes — 4,000 USD across three seasons
Malaria 30 Sep · 1,000 | Tuberculosis 31 Oct · 2,000 | Chagas 30 Nov · 1,000
We know this does not cover the time you spend. It is a way of saying the work had worth.
FINAL-Bench/open-discovery-challenge
Yesterday we opened the third season and 224 arrived within a day: Chagas disease.
Why this disease
Around 6 million people live with it, mostly in Latin America (WHO). Many carry it for decades without knowing, while the heart is slowly damaged. There are two drugs and both date from the 1960s, hard enough to tolerate that many patients cannot finish the two-month course.
Sixty years without a new drug is not only a scientific problem. Most patients live where development costs cannot be recovered, which is why WHO calls this a neglected tropical disease.
But the cost of proposing a candidate and filtering it has changed. So it seemed worth asking whether work nobody funds could be done by many people sharing it out.
The problem this season
The target is CYP51, the enzyme T. cruzi uses to build its membrane sterols. Block it and the parasite cannot survive. The difficulty is that we carry the same enzyme.
Scoring: binding 30 · selectivity 30 · ADMET 15 · whole-cell 10 · novelty 10 · synthesis 5
Selectivity carries 30 points because nobody has solved it. Among the approved azoles on the board as reference compounds, some score 0 on selectivity — not a scorer fault, but the measurement.
Taking part
Design with any model, submit a SMILES, scored within minutes. Five ready-to-paste prompts per season, and the full rubric is published. Your molecule stays yours; private submission is the default.
Prizes — 4,000 USD across three seasons
Malaria 30 Sep · 1,000 | Tuberculosis 31 Oct · 2,000 | Chagas 30 Nov · 1,000
We know this does not cover the time you spend. It is a way of saying the work had worth.
FINAL-Bench/open-discovery-challenge
liked 2
models 12 days ago
Ryzen AI Max+ 395 results: 16.68 tok/s with UD-Q5_K_XL, Vulkan and MTP 4
❤️ 3
12
#41 opened 16 days ago
by 
erstmalreden
I think this model is not ready for use
👀👍 7
20
#40 opened 16 days ago
by 
sa13ma
liked 2
models 17 days ago
liked 5
models 18 days ago
MiniMaxAI/MiniMax-Music3
Text-to-Audio • 2B • Updated • 21.7k • 1.31k
vmlinux/Muse-Glimmer-30B-ROCmFPX-GGUF
Image-Text-to-Text • 28B • Updated • 19k • 18
meta-models/Muse-Glimmer-30B-GGUF
Image-Text-to-Text • 28B • Updated • 489k • 324
deepgrove/maple-preview
Text Generation • 20B • Updated • 7.45k • 380
Lightricks/LTX-2.5
Image-to-Video • Updated • 1.14M • 2.29k
liked a
model 19 days ago
